Fig. 4: The heterogeneity within the T cells. | Cell Death & Disease

Fig. 4: The heterogeneity within the T cells.

From: Deciphering the tumor immune microenvironment of imatinib-resistance in advanced gastrointestinal stromal tumors at single-cell resolution

Fig. 4: The heterogeneity within the T cells.

a 8 subclusters of CD4 T cells were identified by UMAP analysis. b Marker gene expression of each cell type. c Comparison of cell count proportion of each cell type between imatinib resistant and sensitive patients. d, e Expression of FOXP3 and TIGIT in each cell type split by imatinib resistant and sensitive patients. f The coexpression of FOXP3 (red) and TIGIT (green) by polychromatic immunofluorescence method in imatinib resistant and sensitive patients. The Monocle 2 trajectory plot showing the dynamics of CD4 T cell subclusters (g) and their pseudotime curve (h). The exhausted signature (i) and cell death signature (j) expression along trajectory pathway. k The trajectory plot showing dynamics of CD4 T cell subcluster splited by different samples.

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