Fig. 1: Fbw7 deficiency in endothelial cells induces diffuse large B-cell lymphoma in mice. | Cell Death & Disease

Fig. 1: Fbw7 deficiency in endothelial cells induces diffuse large B-cell lymphoma in mice.

From: Selective deletion of E3 ubiquitin ligase FBW7 in VE-cadherin-positive cells instigates diffuse large B-cell lymphoma in mice in vivo

Fig. 1

A Lymphoma incidence in Fbw7ΔEC (n = 36) and WT mice (n = 20). Statistics were determined using Fisher’s exact test. B Macroscopic lymphoma incidence in indicated organs. C Kaplan–Meier plot illustrating time to lymphoma development. Statistical analysis was performed using the log-rank test. D Macroscopic images, H&E, and immunohistochemistry analysis for B220 and CD3e in lymphoma tissue from indicated tissues. Blue and black arrows denote centroblasts and immunoblasts, respectively. Red arrows denote mitotic cells. E Immunofluorescence staining for B220 (green), Ki67 (red), and DAPI (blue) in lymphoma tissues from Fbw7ΔEC mice. F H&E staining of bone marrow from WT and Fbw7ΔEC mice.

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