Fig. 1: PTEN knockout regulates EGFR^L858R-induced lung cancer progression.

The EGFR^L858R*PTEN^-/- mice were generated by crossing the mice of Tet/EGFR^L858R/Scgb1a1/rtTA and Scgb1a1/Cre-ERT2/Pten-loxp mice A, and the mice were genotyped B. The levels of PTEN in the lung tissues of EGFR^L858R and EGFR^L858R*PTEN^-/- mice were studied by IB C and IHC staining D with anti-PTEN antibodies, and then quantitation and statistical analysis were performed; ***p < 0.05. The gross anatomy E and H&E staining of EGFR^L858R and EGFR^L858R*PTEN^-/- mouse lungs F were studied. The levels of CCSP in EGFR^L858R and EGFR^L858R*PTEN^-/- mice was evaluated by IHC staining with anti-CCSP antibodies G.