Fig. 5: PTEN promotes the growth of alveolar cells with EGFR mutation. | Cell Death & Disease

Fig. 5: PTEN promotes the growth of alveolar cells with EGFR mutation.

From: PTEN decreases NR2F1 expression to inhibit ciliogenesis during EGFRL858R-induced lung cancer progression

Fig. 5

The role of PTEN in the cell growth of A549 and PC9 cells with or without GFP-PTEN overexpression or PTEN knockdown was evaluated by cell counting A. The levels of phosphor-AKT (p-Akt) in A549, PC9 B, H1299WT and H1299L858R C cells with or without GFP-PTEN overexpression were measured by IB with antibodies against the indicated proteins. The effect of PTEN on the cell cycles in A549 and PC9 cells with or without GFP-PTEN overexpression was evaluated by flow cytometry D. The statistical analysis was performed by a t-test; *p < 0.05, **p < 0.01, ***p < 0.001, ns: nonsignificant.

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