Fig. 1: The upregulation of RCC1 is correlated with poor prognosis of STS patients. | Cell Death & Disease

Fig. 1: The upregulation of RCC1 is correlated with poor prognosis of STS patients.

From: Targeting RCC1 to block the human soft-tissue sarcoma by disrupting nucleo-cytoplasmic trafficking of Skp2

Fig. 1: The upregulation of RCC1 is correlated with poor prognosis of STS patients.

A The expression level of RCC1 across various cancer types in TCGA database,, along with the Tumor-to-Normal expression ratio. Survival map of hazard ratio (HR) shows the prognostic impacts of RCC1 on multiple cancer type. The red and blue blocks represent higher and lower risks, respectively. The bounding boxes depicted the significant (p < 0.05) unfavorable and favorable results, respectively. B The prognostic analysis between high and low expression of RCC1 in TCGA database. C Kaplan-Meier analysis for RCC1 expression in GSE 30929 patient cohort. D, E Gene set enrichment analysis (GSEA) showed that the samples with high RCC1 expression enriched in DNA replication (NES = 2.647), cell cycle checkpoint (NES = 2.268). The most downregulated gene sets with high RCC1 expression was clustered in regulation of inflammatory response (NES = −2.242), humoral immune response (NES = −2.234).

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