Fig. 7: FBXO32 activates AKT/mTOR pathway and promotes cell cycle process by downregulating PTEN in LUAD. | Cell Death & Disease

Fig. 7: FBXO32 activates AKT/mTOR pathway and promotes cell cycle process by downregulating PTEN in LUAD.

From: FBXO32-mediated degradation of PTEN promotes lung adenocarcinoma progression

Fig. 7: FBXO32 activates AKT/mTOR pathway and promotes cell cycle process by downregulating PTEN in LUAD.

A, B A549 and PC9 cells with stable NC or FBXO32 knockdown and FBXO32/PTEN double knockdown were established. Cell cycle progression was analyzed by FACS. **P < 0.01. *P < 0.1. P values were determined by two-way ANOVA analysis. C The expression of cell cycle-related molecular markers as measured by western blot analysis. D The expression of FBXO32 and the main marker of the AKT/mTOR signalling pathway in A549 and PC9 cells was determined by western blotting. E Schematic diagram showing the regulation mechanism of FBXO32 in LUAD.

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