Fig. 4: In vivo biodegradation of Cripto-PF microspheres assessed by MRI. | Cell Death & Disease

Fig. 4: In vivo biodegradation of Cripto-PF microspheres assessed by MRI.

From: Development of a local controlled release system for therapeutic proteins in the treatment of skeletal muscle injuries and diseases

Fig. 4

The TA muscles of C57-WT mice were injected with 25 µl each of Cripto-Gd-PF or Gd-PF microspheres (with and without cardiotoxin) and imaged using MRI for up to 28 days. A Representative MR images of Gd-labelled PF microspheres injected into the TA muscle (arrows show the location of the implant). The left leg was injected with CTX prior to the Gd-PF microsphere injection, whereas the right leg was administrated without CTX. The bottom panel shows the MR images highlighted with false colors to designate the region of the implant in the CTX-treated muscle (yellow) and in the uninjured muscle (red). B Graphical representation of the segmentation data reveals a reduction in the transient Signal-to-noise (SNR) parameter. C The implant volume parameter (normalized to day 0) exhibits an initial increase followed by a decrease. Data in B and C is presented as mean ± SEM; n = 5 mice per group.

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