Fig. 6: Inhibition of autophagy enhanced the antitumor effects of Nectin-4-MMAE in xenograft tumor models. | Cell Death & Disease

Fig. 6: Inhibition of autophagy enhanced the antitumor effects of Nectin-4-MMAE in xenograft tumor models.

From: A potential strategy for bladder cancer treatment: inhibiting autophagy to enhance antitumor effects of Nectin-4-MMAE

Fig. 6: Inhibition of autophagy enhanced the antitumor effects of Nectin-4-MMAE in xenograft tumor models.

Antitumor effect of Nectin-4-MMAE (3 mg/kg, single dose) in combination with autophagy inhibitor LY294002 (25 mg/kg, twice a week) in HT1376 xenograft. (n = 5 mice). A Tumor growth curve. Black line, Control; green line, LY294002; blue line, Nectin-4-MMAE; red line, combination therapy. **P < 0.01. B Tumor weight. Black dots, Control; green dots, LY294002; blue dots, Nectin-4-MMAE; red dots, combination therapy. **P < 0.01. C Image of tumor tissue. The red cross indicates tumor-free. D–F Hematoxylin and eosin (HE) and immunohistochemical staining for cleaved-caspase 3 and ki67 of tumor tissues from the indicated treatment groups.

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