Table 2 Univariate and multivariate Cox regression analyses for overall survival of gastric cancer patients.

From: ACAT2 suppresses the ubiquitination of YAP1 to enhance the proliferation and metastasis ability of gastric cancer via the upregulation of SETD7

Predictor

Univariate Analysis

Multivariate Analysis

HR (95% CI)

P

HR (95% CI)

P

Age, years

 ≥65 vs <65

1.546 (1.014–2.359)

0.043*

  

Gender

 Female vs Male

1.458 (0.953–2.230)

0.082

  

Size, cm

 >4 cm vs ≤4 cm

2.055 (1.267–3.335)

0.004*

1.770 (1.089–2.876)

0.021*

Tumour location

 Middle 1/3 vs Upper 1/3

0.966 (0.463–2.016)

0.926

  

 Lower 1/3 vs Upper 1/3

0.781 (0.449–1.360)

0.382

  

 More than 2/3 stomach vs Upper 1/3

0.984 (0.525–1.843)

0.959

  

pTNM classification

 II vs I

1.584 (0.206–12.201)

0.659

  

 III vs I

3.791 (0.522–27.541)

0.188

  

Depth of invasion

 T4 vs T2–T3

0.999 (0.532–1.879)

0.999

  

Lymph node metastasis (pN stage)

 N1–N3 vs N0

2.596 (1.376–4.895)

0.003**

2.083 (1.093–3.971)

0.026*

Lauren type

 Diffuse vs Intestinal

1.371 (0.837–2.247)

0.211

  

Expression of ACAT2

 High vs Low

2.932 (1.508–5.701)

0.002**

2.003 (1.010–3.970)

0.047*

  1. pTNM classification is defined using the American Joint Committee on Cancer (AJCC) Staging System, 8th Edition. Asterisks stand for P values as follows: *P < 0.05; **P < 0.01.