Fig. 2: DDP inhibits tumor growth via inducing ferroptosis in vivo. | Cell Death & Disease

Fig. 2: DDP inhibits tumor growth via inducing ferroptosis in vivo.

From: Cancer-associated fibroblasts secrete FGF5 to inhibit ferroptosis to decrease cisplatin sensitivity in nasopharyngeal carcinoma through binding to FGFR2

Fig. 2

Male BALB/c nude mice were randomly divided into five groups (n = 7 per group): control, DDP (1 mg/kg), DDP (2 mg/kg), DDP (4 mg/kg) and DDP (4 mg/kg)+Ferrostatin-1 (10 mg/kg). A Representative photos of xenograft tumors. B, C Quantitative analyses of tumor volume (B) and weight (C). D The immunoreactivity of 4-HNE in tumors was detected by IHC analysis. Scale bar: 50 μm. E The protein levels of GPX4 and SLC7A11 were detected by western blot. (F–H) The levels of MDA (F), Fe2+ (G) and GSH (H) in xenograft tumors were measured using commercial kits. *P < 0.05, **P < 0.01, and ***P < 0.001.

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