Table 1 Autophagy-associated miRNAs in ovarian cancer.
From: The emerging roles of miRNA-mediated autophagy in ovarian cancer
Effect on autophagy | Name | Dysregulation | Target/mechanism | Types of cancer cell line | Ref. |
|---|---|---|---|---|---|
Activation | miRNA-378d | Upregulated | – | KGN | [126] |
Activation | miRNA-342-3p | Upregulated | Enhanced Beclin1 ubiquitination and degradation | SKOV3 and OVCAR3 | [127] |
Activation | miRNA-30d-5p | Upregulated | – | PEO-1 and A2780 | [128] |
Activation | miRNA-29b-3p | Downregulated | – | A2780/paclitaxel | [129] |
Inhibition | miRNA-152 | Downregulated | Reduced ATG14 protein expression | A2780/CP70 and SKOV3/DDP | [130] |
Inhibition | miRNA-8485 | Downregulated | Decreased LAMTOR3 and mTOR expression while increasing ATG13 and LC3-II expression | SKOV3 | [77] |
Inhibition | miRNA-30a | Upregulated | – | A2780 and A2780/DDP | [115] |
Inhibition | miRNA-20a-5p | Upregulated | DNMT3B-induced RBP1 DNA methylation. | A2780, COC1, A2780/DDP and COC1/DDP | [67] |
Inhibition | miRNA-125b | Upregulated | Decreased LC3-II expression | KOV3, COC1 and COC1/DDP | [118] |
Inhibition | miRNA-1305 | Downregulated | The BECLIN1 and VPS34 binding to ARH-I is decreased | OAW42, OVCAR3 and KURAMOCHI | [131] |
Inhibition | miRNA-3127-5p | Upregulated | – | SKOV3, A2780, SKOV3/paclitaxel and A2780/paclitaxel | [78] |
Inhibition | miRNA-133a | Downregulated | Reduced YES1 expression | A2780/DDP and SKOV3/DDP | [116] |
Inhibition | miRNA-219-5p | Downregulated | Decreased LC3-II expression | HEY, HO8910PM, HO8910, SKOV3, SKOV3/DDP, A2780 and A2780/DDP | [79] |
Inhibition | miRNA-4478 | Downregulated | Decrease LC3-II/LC3-I levels and increase p62 levels | IOSE80 and SKOV3 | [69] |
Inhibition | miRNA-506-3p | Downregulated | – | HOSE, OC, SKOV3, A2780, and HO8910 | [76] |
Inhibition | miRNA-144-3p | Downregulated | Decrease Beclin1 and ATG5 expression and increase p62 expression | SKOV3 and A2780 | [75] |
Inhibition | miRNA-214 | Upregulated | – | SKOV3 and IOSE80 | [105] |
Inhibition | miRNA-1251-5p | Upregulated | Autophagosomes were greatly reduced | A2780, HEY, SKOV3, OVCA420, OVCA429, and OVCA433 | [132] |
Inhibition | miRNA-1301 | Upregulated | Inhibited ATG5 and Beclin1 expression | SKOV3 and SKOV3/DDP | [133] |
Inhibition | miRNA-199a-5p | Downregulated | Suppressed autophagy via GSK3β/mTOR complex signaling | SKOV3 | [134] |
Inhibition | miRNA-29c-3p | Downregulated | Inhibited autophagy by downregulating the FOXP1/ATG14 pathway | SKOV3/DDP and A2780/DDP | [135] |
