Fig. 3: Seipin deficiency reduced OL density in mice brains. | Cell Death & Disease

Fig. 3: Seipin deficiency reduced OL density in mice brains.

From: Seipin deficiency-induced lipid dysregulation leads to hypomyelination-associated cognitive deficits via compromising oligodendrocyte precursor cell differentiation

Fig. 3

A Representative images of OLIG2, PDGFRα, or CC1 staining (brown) and X-gal staining (blue) of Seipin-/- mice brain sections. Red dotted boxes show the enlarged fields. B Representative merged images of OLIG2 (green) and PDGFRα (red) double staining. OPCs (OLIG2+PDGFRα+) are indicated by white arrows. OLs (OLIG2+PDGFRα-) are indicated by yellow arrowheads. C Quantification of OL lineage cells (OLIG2+), OPCs (OLIG2+PDGFRα+), and OLs (OLIG2+PDGFRα-) per mm2 in the DG, CA1, CA3, and CC. Graph data were presented as mean ± s.e.m. with n = 5 mice/group. *P < 0.05; ns, not significant (Unpaired t-tests).

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