Fig. 4: Seipin deficiency compromised OPC differentiation in mice brains. | Cell Death & Disease

Fig. 4: Seipin deficiency compromised OPC differentiation in mice brains.

From: Seipin deficiency-induced lipid dysregulation leads to hypomyelination-associated cognitive deficits via compromising oligodendrocyte precursor cell differentiation

Fig. 4

A Representative images illustrating triple-staining of BrdU (red) with OL linage marker OLIG2 (pink) and OPCs marker PDGFRα (green). Yellow arrowheads, proliferating OPCs (BrdU+OLIG2+PDGFRα+). White arrows, newly generated OLs (BrdU+OLIG2+PDGFRα-). B Quantification of proliferating cells (BrdU+), proliferating OL linage cells (BrdU+OLIG2+), proliferating OPCs, and newly generated OLs per mm2 in the DG, CA1, and CA3. C For GO functional analysis of all DEGs in isolated brain tissues from Seipin-/- relative to WT mice, scatter plots show items significantly enriched in the biological process (BP). Graph data were presented as mean ± s.e.m. with n = 4 mice/group. *P < 0.05; ns, not significant (Unpaired t-tests).

Back to article page