Fig. 9: Summary schematic illustrating cognitive deficits induced by Seipin deficiency through impaired OPC differentiation, which is restored by RG administration. | Cell Death & Disease

Fig. 9: Summary schematic illustrating cognitive deficits induced by Seipin deficiency through impaired OPC differentiation, which is restored by RG administration.

From: Seipin deficiency-induced lipid dysregulation leads to hypomyelination-associated cognitive deficits via compromising oligodendrocyte precursor cell differentiation

Fig. 9

Seipin deficiency impaired OPC differentiation, consequent myelination, and spatial cognition. Mechanistically, Seipin deficiency induced lipid dyshomeostasis via interfering expression of sphingolipid metabolism-related genes. RG administration rescued phenotypes induced by Seipin deficiency.

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