Fig. 3: APP-CTFs accumulation in SHSY-5Y cells expressing APPswe induces specific modulation of the expression of mitochondrial transport proteins. | Cell Death & Disease

Fig. 3: APP-CTFs accumulation in SHSY-5Y cells expressing APPswe induces specific modulation of the expression of mitochondrial transport proteins.

From: The amyloid precursor protein and its derived fragments concomitantly contribute to the alterations of mitochondrial transport machinery in Alzheimer’s disease

Fig. 3

A SDS-PAGE of full-length APP and APP-CTFs (C99, C83) levels in control and APPswe cells treated with vehicle (Veh) or with γ-secretase inhibitor (γ-sec inh). B SDS-PAGE of SNPH, Miro1, TRAK1, TRAK2, Kif5 (A, B, and C), Kif5 (low), and IC1, 2 in control and APPswe cells treated with vehicle or γ-secretase inhibitor. Representative SDS PAGE of β-actin is shown as loading controls. Full-length western blots are provided in Supplementary data. Quantitative graphs of SNPH (C), Miro1 and TRAK1 and TRAK2 (D), and Kif5 (A, B, C), Kif5 (low), and IC1, 2 (E) protein levels expressed as means ± SEM of APPswe + Veh (set at 100%). Data were obtained from six independent experiments. **P < 0.01 and ns non-significant versus control or APPswe + Veh using Kruskal–Wallis test and Dunn’s multiple comparison post-test.

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