Fig. 7: A schematic diagram showing that the IL-33/NF-κB/ST2L/Rab37 positive-feedback loop promotes M2 macrophage to limit chemotherapeutic efficacy in lung cancer. | Cell Death & Disease

Fig. 7: A schematic diagram showing that the IL-33/NF-κB/ST2L/Rab37 positive-feedback loop promotes M2 macrophage to limit chemotherapeutic efficacy in lung cancer.

From: IL-33/NF-κB/ST2L/Rab37 positive-feedback loop promotes M2 macrophage to limit chemotherapeutic efficacy in lung cancer

Fig. 7

A The IL-33/NF-κB/ST2L/Rab37 pathway creates a positive feedback loop, leading to increased expression and membrane presentation of ST2L in M2 macrophages, enabling them to respond to the intratumor IL-33. B Blocking IL-33 or ST2L with specific antibodies can inhibit NF-κB activity, suppress the polarization of M2 macrophages, and significantly reduce tumor growth when combined with cisplatin treatment.

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