Fig. 7: NOX4 inhibition with GKT137831 inactivated the Smad2/3, PI3K/Akt, and P38 pathways in HPMCs. | Cell Death & Disease

Fig. 7: NOX4 inhibition with GKT137831 inactivated the Smad2/3, PI3K/Akt, and P38 pathways in HPMCs.

From: Autophagy caused by oxidative stress promotes TGF-β1-induced epithelial-to-mesenchymal transition in human peritoneal mesothelial cells

Fig. 7

GKT137831 (20 μM) decreased the TGF-β1 (2 and 5 ng/mL)-induced phosphorylation of Smad2/3 signaling for EMT (A, B), PI3K and Akt signaling for autophagy (A, C), and the P38 signaling of the MAPK pathway (A, D). The data are presented as mean ± standard error (SE). n = 4 per group. *P < 0.05 vs. control; **P < 0.01 vs. control; ***P < 0.001 vs. control; #P < 0.05 vs. TGF-β1 2 ng/mL; ##P < 0.01 vs. TGF-β1 2 ng/mL; ###P < 0.001 vs. TGF-β1 2 ng/mL; +P < 0.05 vs. TGF-β1 5 ng/mL; ++P < 0.01 vs. TGF-β1 5 ng/mL; +++P < 0.001 vs. TGF-β1 5 ng/mL.

Back to article page