Fig. 8: TREM2 deficiency aggravated IRI-induced renal injury and fibrosis and promoted macrophage polarization in mice. | Cell Death & Disease

Fig. 8: TREM2 deficiency aggravated IRI-induced renal injury and fibrosis and promoted macrophage polarization in mice.

From: TREM2 deficiency aggravates renal injury by promoting macrophage apoptosis and polarization via the JAK-STAT pathway in mice

Fig. 8

a Left; H&E staining of IRI kidneys from WT and Trem2−/− mice. right; H&E results were assessed and quantified as the percentage of the tubular damage area. b Masson staining of IRI kidney tissues from WT and Trem2−/− mice; results were quantified by Image Pro Plus 6.0 software to assess the level of renal fibrosis in mice. c Flow cytometry representative images of CD86+ and CD206+ macrophages in the IRI kidneys of two groups of mice (gated on CD11b+F4/80+ cells). n = 5 per group. *P < 0.05, ****P < 0.0001.

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