Fig. 8: Kat2a deficiency protected DCM from inflammatory injury by inhibiting ferroptosis. | Cell Death & Disease

Fig. 8: Kat2a deficiency protected DCM from inflammatory injury by inhibiting ferroptosis.

From: Histone acetyltransferase Kat2a regulates ferroptosis via enhancing Tfrc and Hmox1 expression in diabetic cardiomyopathy

Fig. 8

A, B TNF-α and IL-6 mRNA levels in NMVCs with Kat2a overexpression or Fer-1 treatment under basal or HG conditions (N = 3 independent experiments). C, D TNF-α and IL-6 mRNA levels in NMVCs with Kat2a knockdown along with Tfrc or Hmox1 overexpression (N = 3 independent experiments). E, F TNF-α and IL-6 mRNA levels in cardiac tissues of mice (N = 7 mice/group). G, H TNF-α and IL-6 protein levels in the cardiac tissues of mice were measured by ELISA (N = 7 mice/group). I Graphical summary of the mechanistic study of this study. Significance tested using One-way ANOVA. Statistical significance is shown as *p < 0.05, **p < 0.01, ***p < 0.001.

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