Fig. 1: Clinical implications of GSDMD-mediated pyroptosis in asthma. | Cell Death & Disease

Fig. 1: Clinical implications of GSDMD-mediated pyroptosis in asthma.

From: Gasdermin D silencing alleviates airway inflammation and remodeling in an ovalbumin-induced asthmatic mouse model

Fig. 1: Clinical implications of GSDMD-mediated pyroptosis in asthma.

A Immunofluorescence staining of N-GSDMD in human airways. B Average optical density (AOD) of N-GSDMD in airway epithelium between control and asthma patients (n = 7 per group). C Ultrathin lung sections were scanned using TEM to assess pyroptosis of airway epithelium in asthma patients and the control group. The red arrow indicates the pyroptosis-related vacuolization structures, the yellow arrow indicates the mitochondria, the green arrow indicates the nuclear membrane of the nucleus. Scale bars: 1μm and 200 nm as indicated. Expression of serum (D) IL-18, (E) IL-1β, (F) IL-17A, and (G) IL-10 were detected in asthma patients and in the control group (n = 20 per group). All the data are presented as means ± SD. *P < 0.05, **P < 0.01, ***P < 0.001.

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