Fig. 3: Gsdmd deficiency reduces the AHR and type 2 immune responses in OVA-induced asthmatic mice. | Cell Death & Disease

Fig. 3: Gsdmd deficiency reduces the AHR and type 2 immune responses in OVA-induced asthmatic mice.

From: Gasdermin D silencing alleviates airway inflammation and remodeling in an ovalbumin-induced asthmatic mouse model

Fig. 3: Gsdmd deficiency reduces the AHR and type 2 immune responses in OVA-induced asthmatic mice.

A The morphological changes of airway were observed by HE staining (left panel). The inflammatory infiltration was quantified by HE scores (right panel). Scale bars: 50 µm. B AHR to increasing doses of methacholine was measured 24 h after the last challenge on WT and Gsdmd−/− mice by recording changes in lung resistance. C IL-4 and D IL-5 secretion in mouse BALF were detected by ELISA. E Total cells number in BALF were counted. Mice groups were the same with panel c and d. F The numbers of neutrophils, eosinophils, lymphocytes and macrophages in the mouse BALF were detected. Results are expressed as mean ± SD. No significance is indicated as NS. n = 10 per group for all experiments. *P < 0.05, **P < 0.01, ***P < 0.001.

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