Fig. 6: Gsdmd deficiency reduces macrophage infiltration in vivo. | Cell Death & Disease

Fig. 6: Gsdmd deficiency reduces macrophage infiltration in vivo.

From: Gasdermin D silencing alleviates airway inflammation and remodeling in an ovalbumin-induced asthmatic mouse model

Fig. 6: Gsdmd deficiency reduces macrophage infiltration in vivo.

Representative images of immunofluorescence staining with antibodies targeting (A) F4/80 and GSDMD, (B) F4/80 and M2 macrophage maker CD206, (C) F4/80 and M1 macrophage maker NOS2 in the lung tissue. Scale bars: 20 µm. D The counts of macrophages and GSDMD positive cells were quantified; n = 4 per group. E The M2/M1 ratio of macrophages was only quantified between OVA-induced WT mice and OVA-induced Gsdmd−/− mice, as the M2 and M1 ratio in WT mice and Gsdmd−/− mice are too low to be calculated and be used for statistical analysis; n = 4 per group. The data are presented as mean ± SEM. Not significant is indicated as NS. *P < 0.05, **P < 0.01, ***P < 0.001.

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