Fig. 9: Schematic diagram shows the function and pathway of GSDMD in asthmatic airway inflammation and remodeling. | Cell Death & Disease

Fig. 9: Schematic diagram shows the function and pathway of GSDMD in asthmatic airway inflammation and remodeling.

From: Gasdermin D silencing alleviates airway inflammation and remodeling in an ovalbumin-induced asthmatic mouse model

Fig. 9: Schematic diagram shows the function and pathway of GSDMD in asthmatic airway inflammation and remodeling.

The expression of N-GSDMD and pyroptosis-related cytokines is significantly increased in the airway epithelium and serum from asthma patients. Pyroptosis is enhanced in an OVA-induced asthma mouse model. Gsdmd deficiency reduces pyroptosis in the asthmatic mice. Gsdmd deficiency in mice significantly attenuates Th17 and Th2 inflammatory responses and M2 macrophage polarization, which contribute to airway inflammation and remodeling. Notch signaling may regulate M2 macrophage polarization upon Gsdmd deletion. The data demonstrate that GSDMD promotes allergic inflammation and tissue remodeling in asthma.

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