Fig. 3: Loss of Yap and Taz has not effect on NK cell development and function. | Cell Death & Disease

Fig. 3: Loss of Yap and Taz has not effect on NK cell development and function.

From: Hippo kinases Mst1 and Mst2 maintain NK cell homeostasis by orchestrating metabolic state and transcriptional activity

Fig. 3: Loss of Yap and Taz has not effect on NK cell development and function.

Representative plots (A) and quantification of the percentage (B, left) and absolute number (B, right) of NK cells in BM and spleen from Yapfl/flTazfl/fl and Yapfl/flTazfl/flCD122Cre mice (n = 5). Representative plots (C) and quantification of the percentage of NKp, imNK, mNK cells among gated CD3−CD122+ cells in BM (D, left) and spleen (D, right) from Yapfl/flTazfl/fl and Yapfl/flTazfl/flCD122Cre mice (n = 4). Representative plots (E) and quantification of the percentage of CD27 SP, DP, CD11b SP NK cell subsets among gated CD3−NKp46+ cells in BM (F, left) and spleen (F, right) from Yapfl/flTazfl/fl and Yapfl/flTazfl/flCD122Cre mice (n = 4). Representative plots (G) and the statistical chart (H) show the percentages of IFN-γ+ NK cells from spleen of Yapfl/flTazfl/fl and Yapfl/flTazfl/flCD122Cre mice (n = 4). Representative plots (I) and the statistical chart (J) show the percentages of CD107a+ NK cells from spleen of Yapfl/flTazfl/fl and Yapfl/flTazfl/flCD122Cre mice (n = 4). K Representative flow cytometry plot (right) and the percentage (left) of rejected RMA-S cells from Yapfl/flTazfl/fl and Yapfl/flTazfl/flCD122Cre mice (n = 7). L Representative flow cytometry plot (left) and the percentage (right) of rejected β2m-/- splenocytes cells in the spleen from Yapfl/flTazfl/fl and Yapfl/flTazfl/flCD122Cre mice (n ≥ 4). Data of A–J are representative of three independent experiments with similar results. Data of K and L are representative of two independent experiments with similar results.

Back to article page