Fig. 2: Overexpression of TBX3 inhibits mouse iCCA growth.
From: Overexpression of TBX3 suppresses tumorigenesis in experimental and human cholangiocarcinoma
A Protein levels of TBX3 in normal livers and Akt/FBXW7ΔF iCCA tumors. GAPDH was used as the loading control. B Study design. FVB mice were hydrodynamically injected with Akt/FBXW7ΔF/pT3 or Akt/FBXW7ΔF/TBX3 plasmids. Mice were sacrificed when bearing large tumors (tumor weight > 4.5 g). C The mice survival curve was plotted when reaching the endpoint. D, E Endpoint liver weight (D) was recorded, and liver weight to body weight ratios (E) were calculated. Student’s t test: p < 0.0001. F Representative gross liver from Akt/FBXW7ΔF/pT3 or Akt/FBXW7ΔF/TBX3 mice at the respective endpoint.
