Fig. 9: Schematic diagram of the roles of coronin 2B in the neuronal nucleolus. | Cell Death & Disease

Fig. 9: Schematic diagram of the roles of coronin 2B in the neuronal nucleolus.

From: Coronin 2B deficiency induces nucleolar stress and neuronal apoptosis

Fig. 9: Schematic diagram of the roles of coronin 2B in the neuronal nucleolus.

Under physiological conditions, coronin 2B localizes at the nucleolus in neurons, where it interacts with UBF and promotes rDNA transcription. MDM2 freely ubiquitinates p53, thereby promoting its degradation. Meanwhile, coronin 2B knockdown impairs the formation of the transcription initiation complex, thereby repressing rDNA transcription. MDM2 is phosphorylated and escapes into the cytoplasm. Furthermore, p53 accumulates and is activated, which subsequently leads to neuronal apoptosis.

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