Fig. 4: SETD8 inhibition significantly impaired ES growth in vivo.
From: SETD8 inhibits apoptosis and ferroptosis of Ewing’s sarcoma through YBX1/RAC3 axis
A Images captured on day 14 posttreatment showcase the excised tumors. B The xenograft tumor growth is depicted through growth curves, with blue arrows marking the days of UNC0379 administration. C A comparative histogram illustrates the distribution of xenograft tumor weights between the control and UNC0379 treated groups. D The weight changes of the mice are tracked over the course of the experiment. E Photographs present the tumors excised from the shNC and shSETD8 groups. F Growth curves of xenograft tumors from both the shNC and shSETD8 groups are displayed. G A histogram contrasts the weights of xenograft tumors between the shNC and shSETD8 groups. H HE staining and IHC images of Ki67 expression in xenograft samples from the DMSO, UNC0379, shNC and shSETD8 groups are provided. ‘ns’ denotes no statistical significance. *p < 0.05, **p < 0.01, ***p < 0.001.
