Fig. 8: Hepcidin amelioration of blood vessel increase and BBB leakage in the cortex of the SAH model. | Cell Death & Disease

Fig. 8: Hepcidin amelioration of blood vessel increase and BBB leakage in the cortex of the SAH model.

From: Hepcidin depending on astrocytic NEO1 ameliorates blood-brain barrier dysfunction after subarachnoid hemorrhage

Fig. 8

A Schematic of hepcidin administration in SAH cortex. Hepcidin was injected into the hemorrhagic side cortex of the SAH mice model. B Representative immunoblotting of hepcidin effect on FPN1 of EC in SAH cortex. C Representative immunoblotting of hepcidin effect on FTH and FTL of EC in SAH cortex. D–F Quantitative analysis of data in (A) and (B) (n = 6 mice/group). 1-way ANOVA with Tukey’s correction for multiple comparisons. G Representative images of dextran 3 kDa leakage in the hepcidin-injected and PBS-injected cortices. H, I Quantitative analyses of dextran leakage and BV length. J Representative images of caveolin-1 coimmunostained with SLC16A1. K Quantitative analysis of data in (J). L Representative images of PLVAP staining in the cortex. M Quantitative analysis of data in (E). Data are presented as mean ± SD (n = 4 mice/group). Scale bars: 20 μm. *P < 0.05; **P < 0.01. Student’s t-test.

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