Fig. 7: MTA1 is upregulated in breast cancer and is a potential cancer biomarker. | Cell Death & Disease

Fig. 7: MTA1 is upregulated in breast cancer and is a potential cancer biomarker.

From: The feedback loop between MTA1 and MTA3/TRIM21 modulates stemness of breast cancer in response to estrogen

Fig. 7

A Immunohistochemical analysis of MTA1, MTA3, and TRIM21 in breast cancer and adjacent normal tissues (n = 10). N adjacent normal tissue, T tumor tissue. B Immunohistochemical staining of normal breast tissue and tumors (histological grades I, II, and III) for MTA1. Representative images of each grade are shown. The percentage of positively stained nuclei (percentage) in the grouped samples was analyzed using a two-tailed unpaired t-test. C Correlation analysis shows negative correlations between the expression levels of MTA1 and MTA3, MTA1 and TRIM21 were negatively correlated in expression. D RFS survival analysis showed that breast cancer patients with high MTA1 expression have a good prognosis. E Survival analysis of clinical data on the relationship between survival time and MTA1/MTA3 and MTA1/TRIM21 expression signatures in breast cancer. Survival curves were calculated using the Kaplan–Meier curves. F Schematic representation of regulatory mechanisms for MTA1, MTA3 and TRIM21 in promoting breast cancer development. Error bars represent the minimum to maximum in B. *p < 0.05, **p < 0.01, ***p < 0.001; two-tailed unpaired t-test.

Back to article page