Fig. 1: Necrotic cell debris and its phagocytic receptors. | Cell Death & Disease

Fig. 1: Necrotic cell debris and its phagocytic receptors.

From: Systemic mechanisms of necrotic cell debris clearance

Fig. 1

A plethora of damage-associated molecular patterns (DAMPs) are released by necrosis, including nuclear and mitochondrial DNA, RNA, histones, nucleosomes, HMGB1 (high mobility group box 1 protein), actin, N-formylated peptides, ATP (adenosine triphosphate), S100 proteins and HSPs (heat shock proteins). Their clearance is mediated by scavenger and pattern recognition receptors on phagocytes. TLR toll-like receptor, cGAS cyclic GMP-AMP synthase, STING stimulator of interferon genes, AIM2 absent in melanoma 2, ZBP1 Z-DNA-binding protein 1, FPR formyl peptide receptor, CLEC C-type lectin receptor, RAGE receptor for advanced glycation end products, SR scavenger receptor, CD cluster of differentiation, LOX-1 lectin-like oxidized low-density lipoprotein receptor-1, SREC-I scavenger receptor expressed by endothelial cells I, P2X/Y purinergic P2X or P2Y receptors, LRP-1 low-density lipoprotein receptor-related protein-1.

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