Table 4 Receptors expressed on LSECs and Kupffer cells (KCs) with their respective necrotic cell debris ligands.

FPR1

N-formylated peptides

H, M +

H +

[164, 165]

CLEC2D

Nucleosomes

?

H +

[29]

CLEC9A

F-actin

R −

R −

[133]

TLR2

Histones

M +

H, M +

[166, 167]

HMGB1

HSPs

TLR3

RNA

M +

H, M +

[166, 167]

TLR4

Histones

H, M +

H, M, R +

[140,166,167,168,169]

HMGB1

HSPs

S100 proteins

TLR7

RNA

M +

M +

[166]

TLR9

DNA

M +

M +

[166, 170]

SR-A1

HSPs

M, R +

M, R +

[133, 171]

SR-B1

S100 proteins

M, R +

H, R +

[133,172,173,174]

CD36

Anionic phospholipids

H +, R +/− #

M, R +

[131, 133, 172, 175, 176]

HSPs

S100 proteins

RAGE

HMGB1

M, R −

H +/−

[174, 177]

S100 proteins

M, R −

LRP-1

HSPs

R +

R +

[178, 179]

LOX-1

HSPs

H +

R +/−

[175, 180, 181]

R −

SREC-I

HSPs

M +

M +

[171]