Fig. 4: HIF1A-AS2 regulates aerobic glycolysis in CRC. | Cell Death & Disease

Fig. 4: HIF1A-AS2 regulates aerobic glycolysis in CRC.

From: HIF1A-AS2 promotes the metabolic reprogramming and progression of colorectal cancer via miR-141-3p/FOXC1 axis

Fig. 4: HIF1A-AS2 regulates aerobic glycolysis in CRC.

A Volcano plot showing the differentially-expressed genes. B Heatmap displaying the expression of some differentially-expressed genes. C Histogram displaying the significantly enriched pathways of upregulated genes. D GSEA results showing the enriched pathways in the sh-NC group. E RNA levels of glycolysis-related genes were determined using RT-qPCR in DLD1 cells. F RNA levels of glycolysis-related genes were determined using RT-qPCR in HCT15 cells. G Representative PET/CT images of the patients in the FUSCC cohort. H SUVmax values of the patients undergoing PET/CT examination in the FUSCC cohort. I Glucose uptake assay of CRC cells after overexpressing or silencing HIF1A-AS2. J Lactate production assay of CRC cells after overexpressing or silencing HIF1A-AS2. K, L ECAR assay of CRC cells after overexpressing or silencing HIF1A-AS2. *P < 0.05; **P < 0.01; ***P < 0.001; ns no significance.

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