Fig. 9: Exosomal HIF1A-AS2 can promote CRC progression. | Cell Death & Disease

Fig. 9: Exosomal HIF1A-AS2 can promote CRC progression.

From: HIF1A-AS2 promotes the metabolic reprogramming and progression of colorectal cancer via miR-141-3p/FOXC1 axis

Fig. 9: Exosomal HIF1A-AS2 can promote CRC progression.

A Relative exosomal HIF1A-AS2 expression in the plasma of 15 healthy people and 15 CRC patients. B ROC curve showing the diagnostic potential of exosomal HIF1A-AS2. C Relative exosomal HIF1A-AS2 level after overexpressing HIF1A-AS2 in CRC cells. D, E The viabilities of CRC cells with relative treatments. F Colony formation assay of CRC cells with relative treatments. G, H Transwell invasion assay and cell migration assay showing the metastatic ability of CRC cells with relative treatments. I, J Glucose uptake assay, lactate production assay, and ECAR assay of CRC cells with relevant treatments. K Cartoon displaying the process about how the exosome was extracted from the supernatant and injected into mice. L Images of subcutaneous tumors, volumes of subcutaneous tumors and weights of subcutaneous tumors. M Representative IHC images showing the expression of Ki67, E-cadherin, and N-cadherin in subcutaneous tumors in different groups. Scale bar = 20 μm. N Representative photographs of bioimaging. O Pictures of mouse liver specimen. P Kaplan–Meier curve comparing the OS between the sh-NC group and sh-HIF1A-AS2 group.

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