Fig. 8: Model for the deregulation of SENP2 leading to genomic instability in cancer cells bypassing the MDC.
From: Sumo-regulatory SENP2 controls the homeostatic squamous mitosis-differentiation checkpoint
Alterations (*) in the expression of SENP2 would trigger the MDC in normal epithelial cells. However, in cancer cells with impaired MDC, it would lead to genomic instability due to mitosis defects.
