Table 2 Combination Index (CI) of MDA-MB-231 (A) and MDA-MB-468 (B) cells treated with JQ-1 (250 nM) and different doses of cisplatin for 72 h. Combination Index (CI) of MDA-MB-231 (C) and MDA-MB-468 (D) cells treated with Dasatinib (0.5 μM) and different doses of cisplatin for 72 h.

From: Targeting of mutant-p53 and MYC as a novel strategy to inhibit oncogenic SPAG5 activity in triple negative breast cancer

A: MDA-MB-231

JQ-1 (nM)

CDDP (μM)

Combination Index

250

0.25

4.250

250

0.5

1.522

250

1

1.640

250

2

0.862

250

4

0.854

250

8

0.741

B: MDA-MB-468

JQ-1 (nM)

CDDP (μM)

Combination Index

250

0.25

4.515

250

0.5

1.031

250

1

0.581

250

2

0.493

250

4

0.559

250

8

0.523

C: MDA-MB-231

DASATINIB (μM)

CDDP (μM)

Combination Index

0.5

0.25

4.247

0.5

0.5

3.637

0.5

1

2.512

0.5

2

1.693

0.5

4

0.911

0.5

8

0.898

D: MDA-MB-468

DASATINIB (μM)

CDDP (μM)

Combination Index

0.5

0.25

4.7186

0.5

0.5

2.737

0.5

1

1.585

0.5

2

0.922

0.5

4

0.775

0.5

8

0.854

  1. Combination Index was calculated by calcusyn software according to the manufacturer’s instructions.
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