Fig. 1: Signal association plots of hepatotoxicity and selected key hepatotoxicity PTs were analyzed for various TKIs in the FAERS database. | Cell Death & Disease

Fig. 1: Signal association plots of hepatotoxicity and selected key hepatotoxicity PTs were analyzed for various TKIs in the FAERS database.

From: The involvement of the Stat1/Nrf2 pathway in exacerbating Crizotinib-induced liver injury: implications for ferroptosis

Fig. 1: Signal association plots of hepatotoxicity and selected key hepatotoxicity PTs were analyzed for various TKIs in the FAERS database.

A Association map of different TKIs with reported hepatotoxicity signals. B Heatmap of the association between different TKIs and selected key hepatotoxicity PTs signals. ALK anaplastic lymphoma kinase, ROS1 ROS proto-oncogene 1, cMET cellular-mesenchymal to epithelial transition factor, EGFR epithelial growth factor receptor, RET proto-oncogene tyrosine-protein kinase receptor ret, HER2 human epidermal growth factor receptor-2, VEGFR vascular endothelial growth factor receptor, CSF-1R colony-stimulating factor 1 receptor, KIT KIT proto-oncogene receptor tyrosine kinase, FLT3 FMS-like tyrosine kinase 3, RAF1 Raf-1 proto-oncogene, serine/threonine kinase, PDGFR platelet-derived growth factor receptors, ROR reporting odds ratio, 95%CI 95% confidence interval.

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