Fig. 6: CCDC113 overexpression promotes CRC tumorigenesis and metastasis in vivo.
From: CCDC113 promotes colorectal cancer tumorigenesis and metastasis via TGF-β signaling pathway
A, B CCDC113 overexpression HCT116 cells and control cells were subcutaneously injected into BALB/c nude mice for 27 days. Representative images of subcutaneous xenograft tumors were shown in left panel. Statistical results of tumor volumes (A) and tumor weights (B) were shown in right panel (n = 4 per group). C, D IHC staining detected CCDC113 expression (C) and Ki67 expression (D) in oeVec group and oeCCDC113 group of subcutaneous xenograft tumors (n = 4 per group). Scale bars, 50 μm. E CCDC113 overexpression HCT116 cells and control cells were injected into tail vein of BALB/c nude mice for 28 days. Representative images of liver metastasis nodules were shown in left panel and statistical results were shown in right panel (n = 4 per group). F Liver metastasis nodules in (E) were analyzed by HE staining. Scale bars, 1 mm. G IHC staining detected CCDC113 and Ki67 expression in liver metastasis tissues (n = 4 per group). Scale bars, 50 μm. Data are presented as means ± SD. ***p < 0.001, **p < 0.01, *p < 0.05.
