Fig. 7: CCDC113 promotes CRC progression via TGF-β signaling pathway.
From: CCDC113 promotes colorectal cancer tumorigenesis and metastasis via TGF-β signaling pathway
A DEGs between shCCDC113 HCT116 cells and shNC cells were shown by volcano plot. B GO enrichment of DEGs in (A). BP Biological Process, CC Cell Component, MF Molecular Function. C KEGG pathway enrichment analysis of DEGs in (A). D GSEA of RNA-seq data between shCCDC113 HCT116 cells and shNC cells. E Correlation analysis between CCDC113 expression and TGF-β signaling pathway according to TCGA database. F Expression of CD24, FERMT1, EPCAM and SLC3A2 in shCCDC113 HCT116 cells and shNC cells according to RNA-seq data. G Correlation analysis of CCDC113 expression with CD24, FERMT1, EPCAM and SLC3A2 expression in CRC according to TCGA database. H Expression of CD24, FERMT1, EPCAM and SLC3A2 in CCDC113 knockdown and overexpression CRC cells were detected by qRT-PCR. I Correlation analysis of CD24, FERMT1, EPCAM and SLC3A2 expression with TGF-β signaling pathway according to TCGA database. J Expression of CD24, FERMT1, EPCAM, and SLC3A2 in CRC tissues according to TCGA and GTEx database. Correlation p values were generated using the stat_cor function in the ggpubr package in R.
