Fig. 5: The role of PI3K/Akt/β-catenin signaling pathway in SPHK1-induced PD-L2 expression. | Cell Death & Disease

Fig. 5: The role of PI3K/Akt/β-catenin signaling pathway in SPHK1-induced PD-L2 expression.

From: SPHK1 promotes bladder cancer metastasis via PD-L2/c-Src/FAK signaling cascade

Fig. 5: The role of PI3K/Akt/β-catenin signaling pathway in SPHK1-induced PD-L2 expression.The alternative text for this image may have been generated using AI.

A The expression of PD-L2 mRNA in T24L or 253J-BV cell lines treated with various inhibitors for PI3K/Akt, ERK, or NF-κB pathway (n = 3). B The inhibitory effect of LY294002 on PD-L2 mRNA and protein expression in 253J cells treated with S1P (n = 3). C The effect of S1P on Akt activation or PD-L2 protein levels in T24LsgSPHK1 or 253J-BVsgSPHK1 cells (n = 3). D The effect of β-catenin OE on Akt activation or PD-L2 protein levels in T24LsgSPHK1 or 253J-BVsgSPHK1 cells (n = 3). The data were presented as mean ± SD and statistically calculated (*p < 0.05, **p < 0.01, ##p < 0.01, ***p < 0.001, ****p < 0.0001).

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