Fig. 6: The central role of PD-L2/c-Src/Y397-FAK-complex in SPHK1-elicited cell migration and invasion of bladder cancer cells.
From: SPHK1 promotes bladder cancer metastasis via PD-L2/c-Src/FAK signaling cascade
A The effect of FAK inhibitor on the interaction of activated FAK protein level with PD-L2 in T24L and 253J-BV cell lines. B The effect of FAK inhibitor on cell migration and invasion of 253J-CA or UC13-CA sublines (n = 3). C The effect of FAK inhibitor on cell migration and invasion of 253J PD-L2 OE subline (n = 3). D The effect of FAK inhibitor on cell migration and invasion of T24L and 253J-BV cell lines (n = 3). E The protein–protein interaction between c-Src, activated FAK, and PD-L2 in 253J PD-L2 OE subline. F The effect of c-Src inhibitor (Dasatinib) on the formation of PD-L2/c-Src/FAK protein complex. The data were presented as mean ± SD and statistically calculated (*p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, ####p < 0.0001).
