Fig. 1: Expression of cIAP1, cIAP2, XIAP and ML-IAP in human GB samples.
From: SMAC mimetic drives microglia phenotype and glioblastoma immune microenvironment
A IAP expression levels were analyzed by Western blotting in hCD45 sorted cells from 4 human GB samples. Expression level of actin β served as loading control. B UMAP representing the different clusters of cells composing the GB tumor microenvironment. Each single cell was mapped to previously published states (n > 1 million cells). C Expression profile of cIAP1/BIRC2, cIAP2/BIRC3, XIAP/BIRC5 and ML-IAP/BIRC7 within the cells of the microenvironment. Note enrichment within TAMs (BDM and MG). D Dot plot representation of the expression of cIAP1/BIRC2, cIAP2/BIRC3, XIAP/BIRC5 and ML-IAP/BIRC7 within the cells of the microenvironment. The size of the dots represents the percentage of cells within the population that express the gene of interest. The color of the dots represents the extent of expression within the plots. DC dendritic cells, Mono monocytes, NK natural killer, OPC oligodendrocyte-precursor cells, RG radial glia, TAM-BDM monocyte-derived cells, TAM-MG microglia.
