Fig. 6: The MAT1A/CCND1 signaling axis promotes glycolysis and tumorigenesis in NSCLC.
From: MAT1A activation of glycolysis to promote NSCLC progression depends on stabilizing CCND1
The xenograft tumor model in nude mice established by A549 cells that interfered with MAT1A and CCND1 expression. After 39 days of monitoring, A tumor volume and B tumor weight was measured. C HE, IHC staining and D WB analysis was performed to determine the expression of MAT1A, CCND1, proliferation marker Ki67 and glycolytic enzymes (ALDOC, HK2) after tumor tissue sections or protein extraction.
