Fig. 4: LAP2α repressing the recruitment of recombination factors to telomeres. | Cell Death & Disease

Fig. 4: LAP2α repressing the recruitment of recombination factors to telomeres.

From: LAP2α orchestrates alternative lengthening of telomeres suppression through telomeric heterochromatin regulation with HDAC1: unveiling a potential therapeutic target

Fig. 4: LAP2α repressing the recruitment of recombination factors to telomeres.

A Analysis of the colocalization of telomere (G-rich probe, green) and RPA2 (antibodies, red) by IF-FISH in U2OS cells were transiently transfected with control siRNA or LAP2α siRNA for 72 h. B Quantification of panel (A). Error bars represent the mean ± SEM of three independent experiments. Two-tailed unpaired Student’s t-test was used to calculate p-values. **p < 0.01. C Analysis of the colocalization of telomere (green) and RAD52 (red) by IF-FISH in U2OS cells. D Quantification of panel (C), respectively. Error bars represent the mean ± SEM of three independent experiments. Two-tailed unpaired Student’s t-test was used to calculate p-values. ***p < 0.001.

Back to article page