Fig. 7: A proposed model depicts how VASH2 promotes chemoresistance and the malignant biological behaviors of LUSC cells by increasing the detyrosination of α-tubulin. | Cell Death & Disease

Fig. 7: A proposed model depicts how VASH2 promotes chemoresistance and the malignant biological behaviors of LUSC cells by increasing the detyrosination of α-tubulin.

From: VASH2 enhances KIF3C-mediated EGFR-endosomal recycling to promote aggression and chemoresistance of lung squamous cell carcinoma by increasing tubulin detyrosination

Fig. 7

VASH2-induced increase in tubulin detyrosination boosts the binding of KIF3C to microtubules and enhances KIF3C-dependent endosomal recycling of EGFR, contributing to the prolonged activation of downstream PI3K/Akt/mTOR signaling and LUSC progression.

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