Fig. 4: Behavioral alterations in Npc1nmf164 mice.
From: Enhanced mGluR5 intracellular activity causes psychiatric alterations in Niemann Pick type C disease
A Graph showing mean ± SEM time spent in the open arm of the elevated plus maze as a percentage of the total exploring time by wt or Npc1nmf164 mice (P < 0.0001; n = 9-10; Student’s t test). B Graph showing mean ± SEM immobility time spent in the tail suspension test as a percentage of the total time by wt or Npc1nmf164 mice (P < 0.0001; n = 9-11; Student’s t test). C Graph showing mean ± SEM of time spent self-grooming by wt or Npc1nmf164 mice (P < 0.0001; n = 7–8; Student’s t test). D Graph showing mean ± SEM of number of marbles buried by wt or Npc1nmf164 mice (P < 0.0001; n = 7–9; Student’s t test). E Graphs show mean ± SEM of nest-building test score (left) and unused cotton material in grams (right) by wt or Npc1nmf164 mice in the nest-building test (Pleft < 0.0001; Pright < 0.0001 n = 7-9; Student’s t test). F Graph showing mean ± SEM of sucrose solution consumption in the sucrose preference test by wt or Npc1nmf164 mice (n = 4; Student’s t test). G Graph showing mean ± SEM of preference index for sociability (stranger 1 vs. empty cage) in the three-chamber test by wt or Npc1nmf164 mice (n = 3–4; Student’s t test). H Graph showing mean ± SEM Graph shows mean ± SEM of preference index for social novelty (stranger 2 vs. stranger 1) in the three-chamber test by wt or Npc1nmf164 mice (n = 3–4; Student’s t test).
