Fig. 7: VCP harbors oncogenic properties via facilitating USP2-mediated stabilization of FASN. | Cell Death & Disease

Fig. 7: VCP harbors oncogenic properties via facilitating USP2-mediated stabilization of FASN.

From: VCP enhances autophagy-related osteosarcoma progression by recruiting USP2 to inhibit ubiquitination and degradation of FASN

Fig. 7

A–C Representative images (left) and the quantification (right) of Edu (A), colony formation (B) and cell apoptosis detection assays showing the growth and the rate of apoptosis of 143B and U2OS cells transfected with Ca-NC, Ca-VCP or co-transfected with Ci-FASN or Ci-USP2. D Immunofluorescence assay for the detection of the fluorescence intensity of cell proliferation protein (PCNA) and cellular anti-apoptotic protein (Bcl-xl) in 143B and U2OS cells stably transfected with Ci-ATG5 or Ca-FASN or co-transfected with Ci-ATG5. Scale bar: 50 µm *P < 0.05.

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