Fig. 5: SQLE enhanced tumorigenic potential of HGSOC cells in vivo. | Cell Death & Disease

Fig. 5: SQLE enhanced tumorigenic potential of HGSOC cells in vivo.

From: Stabilization of SQLE mRNA by WTAP/FTO/IGF2BP3-dependent manner in HGSOC: implications for metabolism, stemness, and progression

Fig. 5

a The tumor-bearing tissues were collected, and the stemness and malignancy of the tumor were detected. b The volume of subcutaneous tumors was detected after injecting OVCAR-3 cells with SQLE knockdown or SQLE overexpression. c The percentage of ALDH-CD133- cells in tumor-bearing tissue was decreased by SQLE overexpression but increased by SQLE knockdown. d The percentage of ALDH+CD133+ cells in tumor-bearing tissue was increased by SQLE overexpression but decreased by SQLE knockdown. The expression of SQLE (e) and Ki67 (f) in tumor samples was analyzed. Cell nucleus were observed by DAPI. Original magnifications for immunohistochemistry were 100× and 400×. *p < 0.05, **p < 0.01, and ***p < 0.001.

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