Fig. 1: The association between the expression levels of SIRT7 in bladder cancer tissues and the efficacy of postoperative chemotherapy.
From: Mechanistic insights into SIRT7 and EZH2 regulation of cisplatin resistance in bladder cancer cells
A, B Representative images of IHC detection of the expression of SIRT7 in bladder cancer tissues. A The IHC images of high SIRT7 expression in bladder cancer tissues. B IHC images of low SIRT7 expression in bladder cancer tissues. C Kaplan-Meier curve analysis comparing the OS of the high and low SIRT7 content groups. D Kaplan-Meier curve analysis comparing DFS between high and low SIRT7 expression groups. A cohort of 126 bladder cancer patients received resection and platinum-based chemotherapy in the study, with their surgical specimens and survival data were examined. Statistical analysis and plotting were performed using the R software. The Kaplan-Meier curve function was employed to compare OS and DFS between patients with high SIRT7 expression and those with low SIRT7 level, with survival curves were constructed. The discrepancy in survival rates was analyzed using the log-rank test to determine significant differences. Statistical significance was defined as a p < 0.05. Scale bar in (A) and (B) is 100 μm.
