Fig. 7: Upregulated expressions of CK2α and DUB3 positively correlate YAP1 expression in ovarian cancer.
From: CK2α-mediated phosphorylation of DUB3 promotes YAP1 stability and oncogenic functions
A Survival curve evaluating the prognostic value of DUB3 in ovarian cancer, pancreatic cancer and breast cancer patients were generated using the Kaplan-Meier plotter. B Survival curve evaluating the prognostic value of YAP1 in ovarian cancer, pancreatic cancer and breast cancer patients were generated by the Kaplan-Meier plotter. C Immunohistochemistry was performed to examine CK2α, DUB3, and YAP1 expressions in ovarian cancer specimens. The expression of YAP1 is positively correlated to DUB3 (D) or CK2α (E) expression in ovarian cancer samples. F Schematic illustration of the finding that CK2α-mediated phosphorylation is crucial for the deubiquitination process of YAP1 by DUB3, thereby promoting cancer progression by stabilizing YAP1.
