Fig. 7: Inhibitor of KLF5 facilitates the cytotoxic effect of oxaliplatin. | Cell Death & Disease

Fig. 7: Inhibitor of KLF5 facilitates the cytotoxic effect of oxaliplatin.

From: Inhibition of KLF5 promotes ferroptosis via the ZEB1/HMOX1 axis to enhance sensitivity to oxaliplatin in cancer cells

Fig. 7: Inhibitor of KLF5 facilitates the cytotoxic effect of oxaliplatin.The alternative text for this image may have been generated using AI.

A–E PDAC cells were treated with ML264 in the presence or absence of oxaliplatin (Oxa) or gemcitabine (Gem), or nab-paclitaxel (nab-PTX), or 5-FU, or irinotecan (Iri) for 48 h, and cell death was detected by PI labeling. CFPAC-1 and Capan-1 cells were subcutaneously inoculated in nude mice. The mice were divided into NC, ML264, Oxa, and ML264+Oxa groups. F, I Tumor size was measured using vernier calipers (**P < 0.01). G, J Tumor growth curves depicted the tumor volumes. H, K MDA levels of the indicated tumors were detected. L Expression of KLF5 and the proliferation marker Ki-67 were detected in tumor tissue sections from the xenografts using IHC staining (n = 5, scale bar, 50 μm).

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